Age-dependent layering of lymphocytes bifurcates infection response
Isaac J. Jensen, Ph.D.
Post-Doctoral Researcher, Farber Lab, Department of Microbiology and Immunology
Columbia University Irving Medical Center
Thursday April 16th, 2026
9:30 – 10:15 am EDT Exhibitor Workshop Room #1 –Exhibit Hall A – Level 1
Extensive lymphocyte compositional and numeric flux occurs in early life as the immune system develops and encounters ubiquitous microbiota exposures, both pathogenic and non-pathogenic. However, how these rapidly evolving immune populations influence one another during infection remains poorly understood. Using spectral flow cytometry, we performed deep immune profiling to resolve complex lymphocyte populations across developmental stages. We demonstrate sequential and coordinate layering of varied lymphocyte (B, T, NK/ILC) populations from birth to adulthood. Consequently, host age bifurcated the intertwined NK and T cell responses during CMV infection eliciting discrete pools of immune memory in infants and adults.
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